Hydrogen-Bond-Dependent Conformational Switching: A Computational Challenge from Experimental Thermochemistry
نویسندگان
چکیده
منابع مشابه
Refoldable Foldamers: Global Conformational Switching by Deletion or Insertion of a Single Hydrogen Bond.
Small changes in the structure of a foldamer may lead to gross changes in conformational preference. We show that the simple insertion or deletion of a single hydrogen bond by changes in pH or by photochemical deprotection is sufficient to refold a helical oligomer, interconverting M and P screw-sense preference. As a consequence of the switch, information may be transmitted to a remote catalyt...
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ژورنال
عنوان ژورنال: The Journal of Organic Chemistry
سال: 2018
ISSN: 0022-3263,1520-6904
DOI: 10.1021/acs.joc.8b02436